PECULIARITY OF THE SPERMATOGENESIS IN DROSOPHILA MELANOGASTER: THE ROLE
OF THE BASIC TRANSPORT RECEPTOR OF THE mRNA (Dm NXF1)
A. A. Acapkina, E. V. Golubkova, V. V. Kasatkina, E. O. Avanesyan,
N. A. Ivankova, L. A. Mamon
Department of Genetics, St. Petersburg State University;
e-mail: gelena@EG10217.spb.edu
Specificity of regulation of genes expression at the transcriptional and posttranscriptional levels is typical
for spermatogenesis in Drosophila and mammals, including humans. It becomes apparent in the existence of testis
specific NXF (nuclear export factor). We have shown that the Dm NXF1 (SBR) protein is present in considerable
amounts at all stages of the spermatogenesis. Using the antibody for the C-terminal part of the Dm NXF1
protein we have shown the cytoplasmic localization of the Dm NXF1 protein at early stages of the spermatogenesis.
This protein is localized in the nuclear envelope at the stage of rounded spermatid. During the period of
elongation, the Dm NXF1 protein has a polar localization, and is located only along one side of the extended
spermatid nucleus. At the stage of spermatid individualization, this protein in the form of large cytoplasmic granules
moves to the tail of the spermatozoon.
Key words: mRNA transport, spermatogenesis, Drosophila, NXF
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