CORRELATIONS OF SISTER CHROMATIDS COHESION COMPLEXES DISTRIBUTION WITH HISTONES H3 AND H4 MODIFICATIONS
A. V. Markov,1,* A. A. Zakharov,1 N. S. Rodionova,1 A. A. Mikhailutsa,1
A. V. Strunnikov,2 A. F. Smirnov 1
1 Department of Selection and Breeding, St. Petersburg State University, and
2 National Institute of Health, NICHD, Unit of Chromosome Structure and Function, Bethesda, USA;
* e-mail: markov@mail.ru
The formulation of «histone code» theory brings active investigations of the role of histone modifications
and other supramolecular factors of DNA condensation in transcription regulation. In this work, we have analyzed
the localization of methylated histones on 9, 36 and 79 lysines, hyperacetylated H4 histone, and subunits of
cohesion complex DRAD21 relatively ot Drosophila melanogaster polytene chromosomes chromatin condensation.
We propose the hypotheses of a cascade regulation of transcription activity defined by histone modifications
and the adaptive role of sister chromatids cohesion in the transcription of high active and extensive genes.
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