GENOTOXIC AND CYTOTOXIC EFFECTS IN BUCCAL CELLS OF CHILDREN LIVING IN ECOLOGICALLY DIFFERENT KUZBASS AREAS
A. V. Meyer,1,* V. G. Druzhinin,1,2 A. V. Larionov,1 T. A. Tolochko 1
1 Kemerovo State University and 2 Institute of Human Ecology SB RAS, Kemerovo;
* e-mail: shapo-alina@yandex.ru
The articee presents the results of the study of micronuclei and other types of cytogenetic aberrations in mucous tunic epithelium cells from children living in two
different parts of the Kemerovo region (Tashtagol city, above-standard radon concentration exposition, n = 80), and Krasnoye settlement Leninsk-Kuznetsk area
(comparison group, n = 41). The samples studied did not differ in the frequency of micronuclei containing cells. Tas-htagol children sample showed significant increase
in the number of binuclear cells, buccal epithelial cells with nuclear protrusions and with nuclear vacuoles, pyknotic cells, and apoptosis bodies. Reliable increase in average
number of cells with chromatin condensation and kayolysis was found in the comparison group. It has been shown that the frequency of metaphase chromosome aberrations
registered in peripheral blood lymphocytes corresponds to the amount of nuclear aberrations detected in buccal epithelium cells using micronuclei test.
Key words: buccal cells, micronuclei, cytogenetic aberrations, nuclear protrusions
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