PROTEASOMES AND THEIR ROLE IN TRANSCRIPTIONAL REGULATION
T. N. Moiseeva,1 A. G. Mittenberg, N. A. Barlev
Institute of Cytology RAS, St. Petersburg;
1 e-mail: t.n.moiseeva@gmail.com
26S proteasome is a multisubunit protein complex that plays a pivotal role in protein degradation. Proteasome's enzymatic activities - proteolytic, ATPase/helicase and
RNase - can be used in regulation of multiple cellular processes. Recent studies confirm the major role of proteasomes in transcriptional regulation. Although various
post-translational modifications of proteasome subunits have been described, relatively little is known about their functional effect on regulation of proteasome-dependent
gene expression. In this article, we talk about the role of proteasomes in control of gene expression and different stages of transcription.
Key words: proteasome, transcription, DNA damage, post-translational modifications
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