ALFA-LIPOIC ACID TRIGGERS ELIMINATION OF CELLS WITH ABNORMAL NUCLEI IN HUMAN CARCINOMA EPIDERMOID CELL LINE
O. P. Kisurina-Evgenieva, G. E. Onishchenko
Department of Cell Biology and Histology, M. V. Lomonosov Moscow State University;
e-mail: evgengeva@mail.ru
The skin is usually exposed to adverse environmental conditions that may cause pathological cell proliferation and cellular transformations leading to the formation of
malignant cells. Antioxidants may affect these processes and induce the elimination of transformed cell. The purpose of this work was to investigate the effect of alfa-lipoic
acid on human carcinoma epidermoid cell line A431. Our results showed that alfa-lipoic acid induced inhibition of cell proliferation or stimulated apoptotic cell death. Cells
with abnormal nuclei were eliminated by apoptosis. Electron microscopy showed that survived cells had typical for control cells shape and organization of the nuclei,
organization of the cytoplasm and organelles. Thus, alfa-lipoic acid not only triggered apoptosis of carcinoma cells, but it may also activate the mechanism of elimination of
cells with abnormal chromosome number.
Key words: alfa-lipoic acid, carcinoma epidermoid cell line, apoptosis, p53
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