VARIATIONS IN CELL POPULATION SIZE AND REACTIVE OXYGEN SPECIES LEVEL IN THE BLOOD AND THE ASCITES LIQUID OF TUMOR CARRIER
Yu. V. Shatalin,1, 2 A. A. Naumov,1 M. M. Potselueva 1, 2,*
1 Institute of Theoretical and Experimental Biophysics RAS, Puschchino, Moscow and
2 Puschchino, Moscow Region;
* e-mail: potselueva@iteb.ru
Using Seidel ascites hepatoma as a model, we studied in detail changes in cell population size and in the level of reactive oxygen species in the tumor growth zone
and in the blood plasma of tumor carrier. It was found that reduction-oxidation conditions in the blood plasma and in the tumor growth zone were different. Thus, because of
hyperactivity and increase in the number of leukocytes, the blood plasma exhibited strong oxidative stress inducing damage to healthy cells, whereas the tumor growth zone
showed the decrease in macrophage concentration, as well as in oxygen and ROS levels. These conditions favor intensive growth of tumor cells.
Key words: polymorphonuclear leukocytes, mast cells, macrophages, histamine, oxidative stress
| Pdf |
Back |
Contents |
Main |
