IS "FIBROBLAST" A SPECIALIZED CELL OR A FUNCTIONAL CONDITION OF MESENCHYMAL CELLS DERIVATIVES?
I. J. Bozo,1 R. V. Deev,1 G. P. Pinaev 2
1 The S. M. Kirov Military Medical Academy and 2 Institute of Cytology RAS, St. Petersburg;
e-mail: romdey@gmail.com
The debatable article is devoted to the analysis of consecutive changes of the notion about the origin, migration, morphofunctional heterogeneity, differentiation and
proliferative potential of the basic cells of a connective tissue - fibroblasts. Despite of a plenty of an actual material on this section of cellular biology, till now there is no
uniform concept about fibroblasts to a full degree defining their cytogenesis, features of phenotypic answers, and position in differon organization. In this article, the data
available in literature are systematized and generalized. The modern outline of fibroblastic differon is offered for the subsequent determination of role and place of its various
parts in normal physiological and pathological reactions of connective tissue.
Key words: connective tissue, fibroblast, origin, migration, morphofunctional heterogeneity, differentiation, proliferative potential
| Pdf |
Back |
Contents |
Main |
