POSSIBLE WAYS OF MSCs INFLUENCE ON THE ISHEMIC TISSUE IN THE CASE OF CARDIOVASCULAR DISEASES
I. B. Sokolova, N. N. Pavlichenko
Trans-Technologies, Ltd., St. Petersburg;
e-mail: natalia-z@alkorbio.ru
Mesenchymal stem cells (MSCs) therapy is a modern and promising approach to the treatment of cardiovascular
diseases. The background of MSCs therapeutic usage was their ability to differentiate into cardiomyocytes
and neuronal lineage cells. It has been experimentally proven that MSCs transplantation accelerates inflammation
in the ischemic region, activates angiogenesis, prevents apoptosis and acts as a protective agent in
the areas adjacent to infarction. This reduces the size of the scar and the volume of damaged tissue, restores the
functioning of the injured organ, and returns the standard rates of behavioral and neurological reactions of the
experimental animals.
Key words: mesenchymal stem cells, differentiation, paracrine function, angiogenesis
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