AMBIGUITY ROLE OF NEUTROPHILS IN ONCOGENESIS
V. N. Maltseva,1 V. G. Safronova
Institute of Cell Biophysics RAS, Pushchino, Moscow Region;
1 e-mail: MaltsevaVN@gmail.com
The review is focused on the participation of polymorphonuclear granulocytes (neutrophils) in development and spreading of a tumor. We consider both the well
known functions of neutrophils (degranulation, production of reactive oxygen species (ROS)) and the recently shown one (presentation of an antigene). The special
attention is focused on the ambiguity of the neutrophil role in oncogenesis. The dominant view is that neutrophils display exclusively antitumor properties. The update
information testifies about protumoral activity of neutrophils: they migrate to a tumor and promote angiogenesis and metastasis at late stages of the tumor. It is
interesting that certain components of neutrophil cytotoxic arsenal (ROS, cytokines, specific enzymes) participate both in antitumoral defenses of an organism and
protumoral activity.
Key words: neutrophils, cytotoxic potential, tumor growth
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