2009. Vol. 51, N 4, p. 311-314

POSSIBILITY OF PREDICTION OF RAT WOUND EPITHELIZATION BY CHANGES OF MATRIX METALLOPROTEINASES LEVELS IN WOUND FLUID M. V. Protasov,1 L. V. Smagina,2 K. M. Yudintseva,2 O. V. Galibin,1 G. P. Pinaev,2 I. V. Voronkina 2 1 Scientific Research Center, I. P. Pavlov St. Petersburg State Medical University and 2 Institute of Cytology RAS, St. Petersburg; e-mail: protasovm@mail.ru The engraftment of a skin sheet together with transplantation of dermal equivalent was studied on rats. The skin sheet was taken as a source of epithelization material in unhealing wound. The process of wound healing was evaluated by changes of matrix metalloproteinases (MMP) activity levels in wound fluid. It was shown that results of skin sheet transplantation could be predicted by monitoring of wound fluid MMP-2 and MMP-9 activity levels. It was determined that skin sheet engraftment appeared at medium values of wound fluid MMP-2 and MMP-9, and transplanted skin sheet was lysed at high and low values. Back    Contents    Main