ALTERNATIVE WAYS OF STRESS REGULATION IN CELLS OF SACCHAROMYCES CEREVISIAE: TRANSCRIPTIONAL ACTIVATORS MSN2 AND
MSN4
T. Y. Erkina, M. V. Lavrova, A. M. Erkine 1
1 Division of Basic Biomedical Sciences, USD Sanford School of Medicine, Vermillion, USA;
1 e-mail: aerkine@usd.edu
Cell response to stress at the transcriptional level is characterized by the rapid expression of a large set of genes. In yeast Saccharomyces cerevisiae
this gene activation is determined by the action of two types of activators - HSF and partially redundant Msn2 and Msn4. While HSF activation mechanisms are
relatively well established during the last decade, the mechanisms of regulation by Msn2/4 started to clarify only recently. Some of the important aspects of Msn2/4
regulation include nuclear-cytoplasmic shuttling and targeted degradation of these factors at gene promoters during transcription activation. These and other
mechanisms will be discussed in the current review.
Key words: Msn2, Msn4, HSF, transcription, chromatin
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