SIGNIFICANCE OF MITOTIC SPINDLE CHECKPOINT GENES IN LEUKEMIA
K. V. Bogdanov
I. P. Pavlov St. Petersburg State Medical University;
e-mail: bogdanov_konstantin@yahoo.co.uk
Leukemia is a clonal proliferative disorder of the multipotent hematopoietic stem cells that leads to abnormal
cell growth and (or) differentiation. The hallmark of the disease is the presence of oncogene expression in
bone marrow or peripheral blood as a result of some chromosome translocations. The development of leukemia
with transfer to disease progression presents a multistage process implicating series of molecular changes leading
to chromosomal instability and aneuploidy. The most possible of these changes include the followings: appearance
of additional chromosome translocations, activation of other not previously expressed oncogenes, loss
of tumor suppressor genes, abnormal centrosome duplication, and dysfunction of the genes which coordinate the
accurate chromosome alignment and chromosome segregation during mitosis. The two latter molecular changes
which are controlled by mitotic spindle checkpoints play the role in leukemogenesis and are probably involved
in apoptosis.
Key words: mitotic spindle checkpoint, mitosis, dysfunction, leukemia, tumor progression
| Pdf |
Back |
Contents |
Main |
