STEROIDOGENESIS-RELATED PROTEINS EXPRESSION IN SKIN CELLS
T. G. Ruksha
Krasnoyarsk State Medical University;
e-mail: tatyana_ruksha@mail.ru
Peripheral benzodiazepine receptor (PBR, TsPO) is an outer mitochondrial membrane protein which is implicated in steroid biosynthesis regulation, apoptosis and
cell proliferation. Immunocytochemical assay revealed decreased levels of PBR, its endogenous ligand DBI and cytochrome P450SCC in malignant skin cells
in comparison to normal keratinocytes and melanocytes. These data indicate diminished steroidogenesis in skin cancer.
Key words: peripheral benzodiazepine receptor, cytochrome P450SCC, steroidogenesis, cell proliferation, skin cancer
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