CYTOGENETIC EFFECTS OF CHOLINOTROPIC PREPARATIONS MIXTURE ON CHIRONOMUS PLUMOSUS (DIPTERA) LARVAE IN VIVO
I. A. Fyodorova,* N. V. Polukonova, N. V. Petrov
Saratov State Medical University;
* e-mail: irina-genet@rambler.ru
Morphometric analysis of changes in nucleolar organizer (NO), Balbiani rings (BR) - BRR, BR1G, BR2G and chromosome I arm
 puff activities, and in chromosome compactness of Chironomus plumosus (Diptera) polytene chromosomes was carried out in acute period under separate and
combined influence of atropine and pilocarpine. Supression effect of cholinotropic preparations mixture was revealed. Suppression of NO activity with atropine concentration
increase in the mixture served as criterion of toxicity.
Key words: cytogenetic effects, polytene chromosomes, m-cholinoblocker, m-cholinomimetic, atropine, pilocarpine, Chironomus plumosus
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