TUMOR ANTIGENS
I. I. Tyuryaeva
Institute Cytology RAS, St. Petersburg;
e-mail: tii@mail.cytspb.rssi.ru
Antigenic distinctions between malignant and normal cells are the key problem of cancer immunology. The researches in this direction allow clarifying
not only the mechanism of cell malignancy, tumor progression and the way it escapes from immuno-surveillance of an organism, but also introduce a
substantial contribution in clinical tumor immunology and immunotherapy. To date, a lot of the facts about antigens of the tumor cells are accumulated.
In the introduced review are given classification and description of tumor antigens. We propose to unite tumor-associated antigens which are characteristic
of normal nonhomologous to tumor tissues in a group of heteroorganic antigens. According to definition, such well-known antigens as cancer/testis antigens
and on-coneural antigens are included in this group.
Key words: tumor antigens, mutant tumor-specific antigens, virus-encoded antigens,
differentiation antigens, onconeural antigens, cancer/testis antigens
Back
Contents
Main
