INVESTIGATION OF THE SURFACE HETEROORGANIC ANTIGENS OF RAT HEPATOMA CELLS
INVOLVED IN PROCESS OF CELL PROLIFERATION
N. P. Teryukova, G. I. Blinova, Yu. M. Rosanov, V. A. Ivanov
Institute of Cytology RAS, St. Petersburg;
e-mail: iva@mail.cytspb.rssi.ru
The investigation of antigenic diversion of hepatoma cells resulting from the expression of heteroorganic
kidney antigens has been continued. Tumor-associated heteroorganic antigens 110—115 and 125—130 kDa were
detected by immunoserum of narrow specificity in fractions of plasmatic membranes of cells of rat ascitic hepatoma
Zajdela and cultured hepatoma HTC; the antigen 75—80 kDa was revealed only for hepatoma Zajdela
cells. It has been shown by methods of radioisotope analysis and flow DNA-cytometry that heteroorganic antigens
110—130 kDa can be involved in process of cell proliferation.
Key words: antigenic diversion, hepatoma, cancerogenesis, tumor-associated antigens
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