MICRONUCLEI IN MUCOSE CELLS AND COLONIZATION OF HUMAN STOMACH EPITHELIUM WITH COCCOID FORMS OF
HELICOBACTER PYLORI
L. V. Kitaeva,1 I. A. Mikhailova,2 D. M. Semov,2 S. N. Proshin,2
V. Yu. Kravtsov 2
1 I. I. Mechnikov State Medical Academy and 2 All-Russian Center of Emergency and Radiation Medicine, St. Petersburg;
1 e-mail: kitaevsfamily@mail.ru
International Agency for Research on Cancer recognized as sufficient the evidence of Helicobacter pylori (HP) infection carcinogenicity and placed it
into the 1st group of carcinogens. Micronucleus level in gastric epithelial cells of antral stomach region of patients with chronic non-atrophy gastritis
(n = 62) was studied. 40 patients of 62 had HP-associated gastritis. The HP-bacterium exists in a spiral and coccoid form. Both morphological forms were
examined using immunocytochemistry. Significantly increased micronucleus number was observed in the cells of HP-infected patients compared with non-infected
person (P < 0.05). The frequency of stomach epithelium cells with micronuclei was enhanced considerably in the patients infected with the coccoid HP form.
Therefore the patients with HP-associated chronic gastritis caused by the coccoid form with high degree of colonization must be considered as a group of enhanced
risk of gastric carcinogenesis.
Key words: Helicobacter pylori, micronucleus, gastric mucosa
Back
Contents
Main
