POLYMORPHISMS OF GENES OF RENNIN-ANGIOTENSINE SYSTEM AND THEIR CORRELATION WITH PSYCHOLOGICAL MANIFESTATIONS OF
BIRTH STRESS
I. M. Spivak,1, * N. A. Sejlieva,1 T. Yu. Smirnova,1 K. M. Bolotskikh,2
V. V. Abramchenko,2 D. L. Spivak 3
1 Institute of Cytology RAS, 2 D. O. Ott Institute of Obstetrics and Ginaecology RAMS
and 2 Human Brain Institute RAS, St. Petersburg;
* e-mail: irina_spivak@hotmail.com
Study of correlation of polymorphisms of genes of the rennin-angiotensine system - insertion-deletion (I/D) polymorphism of the angiotensine-converting enzime
(ACE), and the polymorphism of angiotensinogen (AGT), consisting in submission of T into C in the 704 position (M235T) - with various characteristics of
psychological functioning and clinical characteristics in women giving birth, was conducted. The group consisted of 56 young female Ss, without chronic diseases in
the anamnesis, no complication in the course of pregnancy, birth normal and timely, state of the child normal in all cases. Basing on factor analysis of 7
psychological induces, providing integral assessment of state of the Ss in the course la late pregnancy, giving birth, and the immediately following post partum period,
statistically reliable correlation between such first-rate psychological process as creativity, and polymorphism of the gene of angiotensinogene, was demonstrated,
as well as difference in distribution of genotypes between the group of women giving birth, and general population. Statistically relevant correlation between presence
of the deletion (D) allele of the ACE gene, and heightened level of neuro-ticization, reported by us earlier, was observed in this case, as well. No significant links
between religiosity/spirituality, and genetic data was found. These results are in concordance with present-day views concerning the role of the rennin-angiotensine
system in the providing of active adaptation to stressful conditions; they tend to provide fresh outlook upon the comparative study of input of heredity, and education,
into the ontogenesis of higher psychological functions in normal humans.
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