AN ATYPICAL CASE OF WERNER SYNDROME: EPIGENETIC CONTROL AND DNA DAMAGE RESPONSE ALTERATIONS
N. V. Smirnova, I. M. Spivak, N. M. Pleskach, S. V. Zherebtsov, N. L. Aksenov, V. M. Mikhelson
Institute of Cytology RAS, St. Petersburg;
e-mail: nvsmirnoff@yandex.ru
A case of adult progeria has been described. It has been suggested that this case is an atypical form of Werner syndrome with laminopathy - not WRN
helicase-nuclease defect. During detailed studies of the patient's cells, epigenetic control and DNA damage response alterations were detected.
Back
Contents
Main
|
