CHROMOSOMAL ABNORMALITIES AND SPLEENOCYTE PRODUCTION IN LABORATORY MOUSE MALES AFTER EXPOSURE TO STRESS
CHEMOSIGNALS
E. V. Daev,1, * B. P. Surinov,2 A. V. Dukelskaya,1
T. M. Marysheva 1
1 Department of Genetics and Breeding, St. Petersburg State University, and
2 Laboratory of Radiation Immunology, Medical Radiological Scientific Center RAMS, Obninsk;
* e-mail: edaev@hotmail.com
Activity of antibody producing spleenocytes and chromosome stability in bone marrow cells from laboratory mouse
males of CBA strain after exposure to different chemosignals excreted by stressed or irradiated syngeneic donors was
studied. It has been shown that the exposure of the recipient males to volatiles from donor males (stressed by
swimming) decreases quantity of antibody-producing cells in 1, 3 and 10 days after the treatment. The same exposure
increased the chromosome aberrations level in dividing bone marrow cells from CBA recipients in 1 day after the
treatment. Similar changes were observed in 24 h after exposure to volatiles of irradiated donors or to synthetic
mouse pheromone, 2,5-dimethylpyrazine. Possible mechanisms of chemosignals effect on the immune system are discussed.
Key words: stress, mouse, pheromones, immune system, mitotic disturbances, chromosome stability
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