STRUCTURAL ORGANIZATION AND FUNCTION OF NUCLEAR ENVELOPE
N. V. Gubanova,1 E. V. Kiseleva 2
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Institute of Cytology and Genetics, Siberian Branch of the RAS, Novosibirsk;
e-mail: 1 nat@bionet.nsc.ru,
2 elka@bionet.nsc.ru
Higher-eukaryotic membrane compartmentalization of different processes provides the control of functional
activity in cells. The nuclear envelope that consists of outer and inner nuclear membranes, lamina, and nuclear
pore complexes is one of the most significant and complex cell compartments. It separates DNA replication
and transcription in the nucleus from RNA translation in the cytoplasm and regulates the nuclear-cytoplasmic
transport of different molecules. This review describes and discusses the structural organization and biochemical
composition of different nuclear envelope components (except nuclear pore complexes, which were discussed
in our previous review) as well as its dynamics during mitosis in vitro and in vivo. Special attention
is given to the role of lamina in a group of human genetic diseases, collectively referred to as laminopathies.
Key words: nuclear envelope, lamina, nuclear envelope dynamic, mitosis, laminopathies
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