PATHWAYS OF TRANSDUCTION OF APOPTOTIC SIGNALS IN UNICELLULAR EUKARYOTES
I. V. Schemarova
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAN, St. Petersburg;
e-mail: irina@lis.mail.iephb.ru
The review summarizes current data about transduction mechanism of apoptotic signals by caspase-like enzymes and
mitochondrial apoptogenic proteins in unicellular eukaryotes. The role of receptor-dependent and receptor-independent
caspase cascades is rewieved. The special attention is given to evolution aspects of problem of apoptosis.
Key words: unicellular eukaryotes, intracellular signaling, cell stress, ROS, apoptosis, caspases
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