THE INFLUENCE OF THE EGF ON PROLIFERATIVE SIGNAL TRANSDUCTION IN CILIATE TETRAHYMENA PYRIFORMIS
I. V. Schemarova, G. V. Selivanova, T. D. Vlasova
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS and Institute of Cytology RAS,
St. Petersburg;
e-mail: irina@lis.mail.iephb.ru
It has been shown that the transduction of the proliferative signal induced by EGF in ciliata
Tetrahymena pyriformis cells is not connected with autophosphorylation of the receptor tyrosine kinases.
The results obtained indicate that EGF in ciliata cells initiates the mitogenic pathway including the membrane
proteins of the tyrosine kinases-like type (without tyrosine phosphorylation sites), adenylate cyclase, tyrosine-
and Ca2+-dependent ERK-like kinases.
Key words: Tetrahymena pyriformis, intracellular signaling, tyrosine phosphorylation,
proliferation, EGF, Src-tyrosine kinase, Ca2+, ERK
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