FUNCTIONAL ROLE OF PROTEINS CONTAINING ANKYRIN REPEATS
D. A. Voronin, E. V. Kiseleva
Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk;
e-mail: elka@bionet.nsc.ru
This review describes and discusses new data about the structure and function of proteins which contain ankyrin-
like repeats in their structure. These proteins have been found in cells of different organisms but they are
not belonging to the cytoskeletal proteins. Many important functions of such proteins are provided by ankyrin
repeats which maintain protein-protein interactions involved in the formation of transcription complexes, initiation
of immuno-responses, biogenesis and assembly of cation channels in the membranes, regulation of some
cell cycle stages, symbiotic interactions and many other processes. Mutations in genes encoding ankyrin-like
proteins can cause defects in gene expression leading to diseases onset and progression in animals and humans.
Therefore, the structure, dynamics and function of these proteins is an area of extensive research in modern biology.
Key words: proteins containing ankyrins repeats, protein-protein interaction, regulation of gene expression,
regulation of cell cycle, eukaryotes, prokaryotes
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