THE INFLUENCE OF MYO-INOSITOL ON THE ULTRASTRUCTURE OF HIPPOCAMPAL CA1 AREA IN KAINATE TREATED RATS
M. G. Zhvania,1 R. O. Solomonia, T. Z. Bikashvili, N. T. Kotaria, Ts. G. Chkhikvishvili,
M. T. Kiladze, M. B. Nozadze, N. J. Japaridze
I. S. Beritashvili Institute of Physiology, Tbilisi, Georgia;
1 e-mail: sxgeorgia@sigmaxi.net
The ultrastructure of neurons, synapses and astrocytes of hippocampal CA1 area in rats was investigated 14
days after: systemic injection of kainic acid and kainic acid and myo-Inositol. After injection of kainic acid numerous
neurons with superficial and deep ultrastructural changes of cytoplasmic organelles were described.
Among synapses numerous forms with osmiophilic active zone and single synaptic vesicles, also presynaptic
terminals with core vesicles were often seen. After kainic acid + myo-Inositol injection the cells with superficial
changes of organelles dominated and the synapsoarchitectonics of the area was close to normal. Thus, electronomicroscopic
data indicate possible neuroprotective (antiepileptic?) features of myo-Inositol.
Key words: hippocampal, rat, myo-Inositol, ultrastructure, experimental epilepsy
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