PERSISTENT LOCUS-SPECIFIC INSTABILITY OF YELLOW2-717 AND NOTCHUc-1
IN DROSOPHILA MELANOGASTER COINCIDES WITH HOBO MULTIPLICATION
L. P. Zakharenko,1,2,* L. V. Kovalenko,1 S. Mai,3
I. K. Zakharov 1,2
1 Institute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk,
2 Division of Cytology and Genetics, Novosibirsk State University, and
3 Institute of Cell Biology, Winnipeg, Canada;
* e-mail: zakharlp@bionet.nsc.ru
According to FISH data the presence of multiple hobo element copies in the unstable yellow and
Notch loci in y2-717 and Uc-1 Drosophila melanogaster stocks, respectively, was
found. Locus-specific instability in these strains is caused by hobo multiplication in the respective loci and its
subsequent recombination with neighboring hobo copies rather than its insertion-excision.
Key words: Drosophila melanogaster, hobo-element, genomic instability, FISH,
yellow, Notch
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