CELL ASPECTS OF PATHOGENESIS OF HYPERTROPHIC CARDIOMYOPATHY: THE ROLE OF CARDIOMYOCYTE POLYPLOIDY
AND ACTIVATION OF THE PROLIFERATING CELL NUCLEAR ANTIGEN IN MYOCARDIUM
E. V. Shlyakhto,1 L. A. Bokeria,2 M G. Rybakova,1
E. N. Semernin,1 G. V. Selivanova,3 T. D. Vlasova,3 K. V. Borisov,2
V. N. Parfenov,3 A. Y. Gudkova 1
1 G. F. Lange Chair of Faculty Therapy of I. P. Pavlov State Medical University, St. Petersburg,
2 A. N. Bakulev Research Center of Cardiosurgery, Moscow,
and 3 Institute of Cytology RAS, St. Petersburg;
1 e-mail: alexgucl@spmi.rssi.ru
Mechanisms of hypertrophy development in hypertrophic obstructive cardiomyopathy (HOCM) have not
been enough investigated. In our study, there have been examined patients with severe HOCM at different ages,
including children, and patients with essential arterial hypertension (EAH). There was found, that HOCM in
children compared to adults was characterized by considerable interventricular septum (IVS) hypertrophy and it
was accompanied by the acceleration of cardiomyocyte polyploidy. The average ploidy level of cardiomyocytes
in children with HOCM was higher than analogous indices in adults. The average ploidy level of nuclei, the part
of PCNA-positive nuclei and polyploidic nuclei of cardiomyocytes in aduls with HOCM were authentically higher
than in patients with EAH. Activation of the nuclear antigen in stromal cells was detected only in patients
with HOCM. Our findings provide evidence of an important role of cardiomyocyte polyploidy and activation of
the proliferating cell nuclear antigen in development of the myocardial hypertrophy in patients with HOCM.
Key words: hypertrophic obstructive cardiomyopathy, polyploidy, cardiomyocytes, stromal cells
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