MODULATION OF PROGRAMMED DEATH OF THE PERIPHERAL BLOOD LYMPHOCYTES UNDER CHRONIC VIRUS INFECTION
O. B. Zhukova,1 N. V. Ryazantseva, V. V. Novitskiy, T. T. Radzivil,
L. S. Litvinova, N. Yu. Chasovskikh
SEI HPE Siberian State Medical University, Health Department of the Russian Federation, Tomsk;
1 e-mail: cnil@mail.ru
We investigated programmed death of lymphocytes in patients with chronic infections - tick-borne encephalitis,
hepatitis B and C. It has been shown that the character of disorders in realization of lymphocyte apoptosis depends
on molecular features of the infectious agent. Apoptotic death of lymphocytes was elevated after incubation
in vitro with dexamethazone, etopozide and in medium without serum. Receptor-dependent and mitochondrial
paths of apoptotic signal conduction are preferentially modulated under chronic virus persistence.
Key words: lymphocyte, chronic virus infection, apoptosis, modulation, Fas-receptor, TNF-receptor,
mitochondrial membrane potential
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