DISCRIMINATION OF HETEROZYGOTE CURRENCY OF ATAXIA-TELANGIECTASIA BY INDIRECT IMMUNOFLUORESCENT ANALYSIS
I. M. Spivak, N. I. Smirnova, N. M. Pleskach, T. A. Ledashcheva, V. M. Mikhelson
Institute of Cytology RAS and Municipal Consultation-Diagnostic Medical Genetics Centre, St. Petersburg;
e-mail: irina_spivak@hotmail.com
The qualitative differences in P53 protein stabilization after ionizing irradiation in different doses were found
in cells of members of ataxia-telangiectasia (AT) family-proband AT6SP, her sister AT(S)6SP and father AT(F)6SP.
The method of indirect immunofluorescence with confocal microscopy was used.
Key words: ataxia-telangiectasia, P53, ionizing radiation, heterozygote currency
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