INVESTIGATION OF PROPERTIES OF THE THERMOSTABLE PROTEIN COMPLEX OBTAINED FROM THE MYOCARDIUM LEFT VENTRICLES OF
ADULT WHITE RATS
N. M. Giorgobiani,1 D. V. Dzidziguri,1 L. P. Rusishvili,1
E. M. Giorgobiani,2 M. R. Chkhobadze,1 G. D. Tumanishvili 1
1 Tbilisi State University after I. Javakhishvili, and
2 Institute of Experimental Morphology after Al. Natishvili, Tbilisi, Georgia;
e-mail: nana_giorg@yahoo.com
A thermostable protein complex (TSPC) obtained from the myocardium ventricules of adult rats inhibits mitotic and
transcriptional activity of cardiomyocytes. At the same time this complex is more active on early stages of the
postnatal ontogenesis in rats, aged 1 and 5 days. Following its action on RNA synthesis, the TSPC reveals tissue
specificity only in cells with terminal differentiation, and is determined by its nuclear membranes. We continue
studies for identifying the molecular weight and chemical nature of the TSPC, and the role of its different fractions
in regulation of proliferation processes. Besides, it is planned to produce antibodies against TSPC fractions with
the purpose to block its inhibitory effect on myocyte regeneration in the damaged myocardium.
Key words: growth factors, transcription factors, myocardium proliferation, organ specificity
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