ON THE LIVER REGENERATIVE POTENTIAL OF THE LAKE FROG RANA RIDIBUNDA AFTER PARTIAL HEPATECTOMY
A. F. Karapetyan, K. A. Jivanyan
Yerevan State University, Republic Armenia;
e-mail: annakarapetyan@ysu.am
A histomorphological study of the regenerating liver of Rana ridibunda, within 2 months after partial
hepatectomy, shows that regenerative processes on the wound surface are slowly proceeding. Processes of reticular
fiber reconstruction occurred in the composition of the basal membrane of liver sinusoids. A cytophotometric study
shows that glandular cells in R. ridibunda liver are commonly tetraploid. The post-traumatic regeneration of
the liver after partial hepatectomy involves activation of DNA synthesis in hepatocytes, leading to increase in
their ploidy. Within the 1st month of regeneration, the mitotic index of hepatocytes substantially increased.
Regeneration of glandular parenchyma of the liver is accompanied by a quantitative increase in binucleate
hepatocytes, which is most highly expressed within 5-20 days after partial hepatectomy.
Key words: Rana ridibunda, partial hepatectomy, liver regeneration, mitotic index
Back
Contents
Main
