THE ROLE OF PROTEIN KINASE CASCADES IN STRESS SIGNAL TRANSDUCTION IN UNICELLULAR EUKARYOTES
I. V. Shemarova
Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg;
e-mail: irina@lis.mail.iephb.ru
The review summarizes current data on transduction mechanisms of stress signals by protein kinase cascades in
unicellular eukaryotes. The role of sensor histidine kinases, tyrosine kinases, PKC, and cyclic nucleotid-dependent
kinases are reviewed. Special attention is paid to a comparative analysis of transduction mechanisms of stress
signals in vertebrates and unicellular eukaryotes.
Key words: unicellular eukaryotes, intracellular signaling, stress, sensor proteins, cAMP,
histidine kinase, PKC, PKA, MAP-kinase cascade
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