SOME FEATURES OF ENDOTHELIAL ULTRASTRUCTURE OF MYOCARDIUM MICROVESSELS AFFECTED BY VARIOUS METHODS OF ARTIFICIAL
HYPOTHERMIA
G. M. Kazanskaya
Research Institute of Circulation Pathology after Yu. N. Meshalkin, Federal Health Care & Social Development
Agency, Novosibirsk
A comparative analysis of the endothelial ultrastructure of myocardium microvessels affected by various
methods of artificial hypothermia was carried out. Tissue samples were harvested in children with a congenital
ventricular septum defect after cooling the whole body under the conditions of hypothermic artificial circulation
and perfusionless (immersion) hypothermia. It was found out that the shifts in population composition of endothelial
cells, as well as the changes in the ultrastructure of organelles participating in endocellular syntheses and
transendothelial transfer of macromolecules depended upon the rate body cooling. Under perfusionless hypothermia and
of moderately low cooling rate, morphological signs of inhibition of endothelial cells metabolism were observed
alongside with quantitative reduction of their micropinocytic transport indicators. Under hypothermic artificial
circulation these reactions tended to lag behind due to the high cooling rate that initiates a heterogenic response
of various endothelial processes to the changes of body temperature.
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