THE FILAMIN IN CELL SIGNALING
F. M. Komaletdinova, G. P. Pinaev
Institute of Cytology RAS, St. Petersburg
This review describes structure and functions of the group of actin-binding proteins - the filamins.
Up-to-date facts demonstrate that filamis take part in different regulatory processes in the cell. The filamins have
diverse functions - organization of actin polymers into orthogonal networks (three-dimensional scaffolding),
attachment of actin filaments to transmembrane receptors, regulation of actin-myosin interaction, regulation of
actin assembly. In addition to its main role of the cytoskeleton structural protein, filamin can serve as scaffold
protein for formation of signal proteins complexes. One interacts with transcription factors and takes part in signal
transduction from cytoplasmic membranes to the nucleus. C-terminal end of filamin interacts with androgen receptor
and through cleavage by calpain translocates to the nucleus. Analysis of reviewed experimental dates suggests the
conception that intracellular signalization mediated by cytoskeleton proteins is connected with reorganization of the
cytoskeleton.
Key words: filamin, signaling, transcription factors, cytoskeleton
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