TESTOSTERONE'S ROLE IN REGULATING EXPRESSION OF GENES OF SEVERAL PROLIFERATION FACTORS
A. V. Pechersky,1,* O. B. Loran,2 V. I. Pechersky,3
M. S. Vonsky,4 A. G. Mittenberg,4 V. F. Semiglazov 5
1 St. Petersburg Medical Academy of Post-Graduate Studies,
2 Russian Medical Academy of Post-Graduate Studies, Moscow,
3 P. F. Lestgaft State Academy of Physical Education,
4 Institute of Cytology RAS, and
5 The N. N. Petrov Research Institute of Oncology, St. Petersburg;
* e-mail: a_pechersky@msn.com
This research work focuses on an important topic - the study of cause and effect links between partial androgen
deficiency of ageing men (PADAM) and an increased expression of genes of a series of factors that make proliferate
activity. The results of this research show that an increased expression of genes of several proliferation factors,
and a decreased expression of the gene of the insulin receptor among men of older age groups are all connected to
PADAM. The given changes are directed at compensation for testicular inadequacy, and are a particular expression of
metabolic syndrome (X-syndrome); their effect can be inversed however by androgen-replacement therapy.
Key words: ER, main fibroblast growth factor, epidermal growth factor, insulin, IR, bcl-2, PSA
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