LOW-MOLECULAR PEPTIDES FROM TISSUES OF HIBERNATING AND COLD-ADAPTED
ANIMALS INFLUENNE CELL PROLIFERATION IN THE EHRLICH ASCITIC CARCINOMA
A. K. Gulevsky, V. I. Grishchenko, O. S. Tereshchenko, I. J. Shchenyavsky
Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of the
Ukraine, Kharkov;
* e-mail: ivanou@rambler.ru
Polypeptides with cytostatic activity are known to be present in animal tissues during winter dormancy. A
1—10 kDa polypeptide fraction with cytostatic activity was obtained from brain tissue of hibernating ground
squirrels and cold-adapted Yakut horses. The pattern of cytostatic activity of this fraction towards tumor cells is
of great interest. We present results testifying to cytostatic activity of this fraction towards the Ehrlich ascitic
carcinoma cells. The cytostatic effect is realized in tumor cells at the genetic level.
Key words: Ehrlich ascitic carcinoma, hibernating and cold-adapted animals, proliferation, cytostatic effect
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