KINETIC FEATURES OF A WHITE RAT HEPATOCYTE POPULATION UNDER HORMONAL DISBALANCE BEFORE AND AFTER PARTIAL
HEPATECTOMY
D. V. Dzidziguri,1 B. N. Kudiyavtsev,2 I. R. Modebadze,1
A. V. Arkadyeva,2 E. D. Bakuradze1
1 Department of Cytology, Histology and Development Biology, State University after
Iv. Javakhishvili, Tbilisi, Georgia, and
2 Institute of Cytology, RAS, St. Petersburg, Russia;
e-mail: ldb@access.sanet.ge
Bilateral adrenalectomy, followed in 4 days by a partial hepatectomy, was performed using white rats weighing
as much as 120-140 g. Under hormonal disbalance caused by bilateral adrenalectomy, the number of polyploid
(4c, 4c x 2, and 8c) hepatocytes significantly increased, compared to that in non-operated control rats.
Six hours after a partial hepatectomy, the share of highly ploid hepatocytes falls, being accompanied by a 9-fold increase in
mitotic index. It is supposed that under hormonal disbalance condition, a partial hepatectomy may induce "early" mitoses in
hepatocytes blocked in G2-phase of the cell cycle.
Key words: adrenalectomy, partial hepatectomy, G2-hepatocytes population
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