CHANGES IN THE EXPRESSION OF RECEPTORS OF STEROID HORMONES IN THE DEVELOPMENT OF PARTIAL ANDROGEN DEFICIENCY OF
AGING MEN (PADAM)
A. V. Pechersky,1 V. F. Semiglazov,2 B. K. Komyakov,3
B. G. Guliev,4 A. I. Gorelov,5 A. I. Novikov,3 V. I. Pechersky,6 N. N. Simonov,2
A. V. Gulyaev,2 I. A. Samusenko,3 M. S. Vonsky,7 A. G. Mittenberg,7
O. B. Loran 8
1 St. Petersburg Medical Academy of Post-Graduate Studies,
2 N. N. Pctrov Research Institute of Oncology, St. Petersburg,
3 St. Petersburg State Medical Academy after I. I. Mcchnikov,
4 Municipal Multi-Profile Hospital ¹ 2, St. Petersburg, 5 St. Petersburg State University,
6 P. F. Lestgaft State Academy of Physical Education, St. Petersburg, 7 Institute of Cytology, RAS,
St. Petersburg, and 8 Russian Medical Academy of Post-Graduate Studies, Moscow, Russia;
e-mail: a_pechersky@msn.com
This work is devoted to the vital topic of the influence of partial androgen deficiency of aging men (PADAM)
on the development of cells with androgen receptors. The results obtained in this study suggest a conclusion that the production
of testosterone by some tumors and tissues of the peritumorous zone, which is accompanied by increased proliferative activity
and disturbance of the regulation of the cell cycle, is caused by PADAM. The given changes are directed at compensating for
testicular deficiency (in particular at overcoming the androgen-dependent stage of development of androgen-sensitive cells).
These changes are a partial manifestation of metabolic syndrome (X-syndrome). The atypical cells, which unavoidably develop
during metabolic syndrome, are dealt with by means of the immune system, whose capabilities become less and less adequate in the
given circumstances.
Key words: bladder cancer, PADAM, prostate cancer, rectal cancer, AR, ER, PR, bcl-2, Ki67, p53
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