POSSIBLE PROTECTIVE ROLE OF AUTOTYPIC CONTACTS UNDER CEREBELLAR NEURAL NET INJURY BY TOXIC DOSES OF NO-GENERATIVE
COMPOUNDS
N. V. Samosudova,1 * V. P. Reutov,2 N. P. Larionova,1
L. M. Chaylakhyan 3
1 Institute of Information Transmission Problems, RAS,
2 Institute of Higher Nervous Activity and Ncurophysiology RAS. Moscow, and
3 Institute of Experimental and Theoretical Biophysics, RAS, Puschino, Russia;
1 e-mail: samosudova@mail.ru
In the present work, cerebellar neural net injury was induced by toxic doses of NO-generative compound
(NaNo2). A protective role of glial cells was revealed in such conditions. The present results were compared with those
of the previous work concerning the action of high concentration glutamate on the frog cerebellum (Samosudova et al., 1996). In both
cases we observed the appearance of spiral-like structures - "wrappers" - involving several rows of transformed glial processes with
smaller width and bridges connecting the inner sides of row (autotypic contact). A statistic analysis was made according to both
previous and present data. We calculated the number and width of rows, and intervals between bridges depending on experimental
conditions. As the injury increased (stimulation in the NO-presence), the row number in "wrappers" also increased, while the row width
and intervals between bridges decreased. The presence of autotypic contacts in glial "wrappers" enables us to suppose the involvement
of adhesive proteins - cadherins in its formation. The obtained data suggested that the formation of spiral structures - "wrappers"
may be regarded as a compensative-adaptive reaction on the injury of cerebellar neural net glutamate and NO-generative compounds.
Key words: cerebellum, nitric oxide (NO), nitrites, neurons, glia, autotypical contacts
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