Chromosomes/chromatids transport to cell division poles (chromosome segregation) and nuclear-cytoplas-mic transport give
way to each other during cell cycle. Disassembly and reassembly of the nuclear envelope during input or output mitosis are the critical
time periods for changing one kind of transport system for the other one. The interest in the problem of relationships between
nuclear-cytoplasmic transport and chromosome segregation came into view after revealing some factors involved in both transport systems.
Among these factors are GTPase Ran, nuclear transport receptors and associated molecules, kinetochore proteins and proteins of nuclear
pore complexes (nucleoprin, for example), spindle microtubulcs, microtubule motor proteins, and signal molecules. The role of all of
these factors in the transport systems is not known. A decision of this problem will make it possible to determine mechanisms of both
transport systems and to understand the character of evolutionary relationships between these systems.
Key words: nuclear-cytoplasmic transport, chromosome segregation, nuclear envelope, kinetochore, nuclear pore
complex
