EFFECT OF TESTOSTERONE CONCENTRATION ON THE INTENSITY OF 5α-DIHYDROTESTOSTERONE
AND 17β-OESTRADIOL FORMATION
A. V. Pechersky,1, * V. I. Mazurov,1 V. F. Semiglazov,2
A. I. Karpischenko,3 A. V. Udintsev 3
1 Medical Academy of Post-Graduate Education, 2 The Pctrov Institute of Oncology,
and 3 The Russian Military Medical Academy, St. Petersburg, Russia;
* e-mail: a_pechersky@msn.com
The culture of human male foreskin fibroblasts was incubated with various concentrations of testosterone in the medium.
It has been shown that the minimum formation of 17β-oestradiol and 5α-dihydrotestosterone occurs at physiological testosterone
concentrations. Any deviation of testosterone concentration, both up and down, was accompanied by an increase in the formation of
17β-oestradiol and 5α-dihydrotestosterone.
Key words: fibroblasts, testosterone, 17β-oestradiol, 5α-dihydrotestosterone
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