PHENOMENA OF "MICRONUCLEOLI" IN CARDIOMYOCYTES FROM PATIENTS WITH IDIOPATHIC
RESTRICTIVE CARDIOMYOPATHY
A. Ya. Gudkova, E. V. Shlyakhto
Chair of Internal Medicine after G. F. Lang, St. Petersburg Pavlov State Medical University, Russia;
1 e-mail: Alexgud@spmu.rssi.ru
Silver staining was used to estimate structural and functional conditions of cardiomyocyte and stromal cell nucleoli in
myocardium from 3 patients with idiopathic restrictive cardiomyopathy (RCM). We revealed a prominent increase in the amount of myocardial
stromal component cells. The area of nuclei, the area and amount of nucleoli in cells of myocardial stromal component much varied. In
some cells of myocardial stromal component we found nuclei, whose area was comparable with that of cardiomyocyte nuclei. In all patients
we revealed cardiomyocytes with extranucleolar distribution of argentophilic substance in the nuclei. These data suggest an important
pathogenic role of structural rearrangments in the nuclei of cardiomyocytes and stromal component cells in providing specific cell
phenotype of myocardium in patients with idiopathic RCM. Extranucleolar (atypical) distribution of argentophilic substance in the
nucleus, referred to as "micronucleoli", point out certain disturbances of nucleolar functions in cardiomyocytes in patients with RCM.
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