SOME STABILIZATION FEATURES OF P53 PROTEIN IN GAMMA-IRRADIATED CELLS OF PATIENTS WITH ATAXIA-TELANGIECTASIA
I. M. Spivak,1 N. V. Smirnova,1 N. M. Pleskach,1
T. A. Ledascheva,2 V. M. Mikhelson 1
1 Institute of Cytology RAS and 2 Municipal Consultation-Diagnostic
Medical Genetics Centre, St. Petersburg, Russia;
e-mail: irina_spivak@hotmail.com
Stabilization of P53 protein in cells isolated from patients with a grave hereditary disease
ataxia-telangiectasia (AT), characterized by strongly enhanced sensitivity to ionizing radiation and impairment of cell cycle
control after DNA damage, was studied. The level of expression of these reactions by patients may vary, and it tends to be linked
with the severity of the disease. In all AT strains studied, both acquired by the authors and obtained from foreign colleagues,
we observed the alteration of timing and character of stabilization of P53 protein, after the action of ionizing radiation in
sublethal dosage, as compared to that in cells from healthy donor.
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