A STUDY OF CHROMOSOMAL FRAGILITY IN PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH
LYMPHOMAS
O. V. Mikhailovskaya, N. A. Viktorova, O. R. Krasnova, A. A. Titova, S. N. Kolyubaeva
Medico-Military Academy, St. Petersburg, Russia;
Patients with lymphomas were shown to have authentically a higher frequency of fragile sites, both spontaneous and
induced by aphidikoline expression, in comparison with the control group. Differential sensitivity of chromosomes caused by the
action of aphidikolin was revealed. The fragility of chromosomes 9 and 11 in patients with lymphomas on sites 9q31-32 and 11pl3-14
was authentically higher (α = 0.05) than that in healthy individuals. Site 9q31-32 appeared to be strictly specific for lymphoma
disease.
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