THE INFLUENCE OF TUMOR GROWTH ON NATURAL CYTOTOXICITY AND ACTIVITY OF SOME LYSOSOMAL
ENZYMES OF HUMAN EFFECTOR CELLS AND THE C3HA MOUSE SPLENOCYTES
O. N. Pogodina, A. G. Bulychev
Institute of Cytology RAS, St. Petersburg, Russia;
e-mail: cellpath@mail.cytspb.rssi.ru
In the course of malignant growth processes in patients with lung cancer, a decrease of natural cytotoxic activity of
peripheral blood lymphocytes was observed. This process was accompanied by changes of activities of two lysosomal enzymes,
arylsulfatase and acid phosphatase, suggesting participation of these enzymes in manifestation of effector functions of lymphocytes in
cancer patients. The level of activity of granular enzyme, β-glucuronidase, remained unchanged at all stages of disease. A study of
natural killer activity of C3HA mice splenocytes after inoculation of transplantable hepatoma 22-a cells revealed a relative stability of the
level of their cytotoxicity, and of the activities of lysosomal enzymes - arylsulfatase, acid phosphatase, α-mannosidase, acid lipase,
N-acetyl-β-D-glucosidase, and β-galactosidase, beginning from the 3rd day after hepatoma implantation.
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