SOME PECULIARITIES OF EPITHELIAL-STROMAL INTERACTIONS IN PERITUMOROUS ZONE OF THE PROSTATE
GLAND CANCER
K. V. Fedosenko, A. V. Pechersky, A. I. Karpishchenko
City Postmortem Bureau, Medical Academy of Postgraduate Education, and
Russian Military Medical Academy, St. Petersburg, Russia;
e-mail: a_pechersky@msn.com
This article deals with an urgent topic - assessment of peculiar characteistics of epithelial-stromal interactions in
prostate gland tissues outside the tumor growth zone. On demonstrating pre-cancerous changes, this zone can either further accompany
or precede the development of malignant neoplasm. The authors have established suppression of general morpho-functional activity of
histogematogenous barrier components, increase in degenerative changes in epithelium, both in the vicinity of the tumor, and at a distance
from it, which is, most probably, caused by dishormonal changes. We demonstrated the growth of lymphocytic-monocytic infiltration, and a
decreased number of fibroblasts and endothelial cells of prostate gland tissues outside the tumor growth zone. The discovered changes
of the histogematogenous barrier condition in the peritumorous zone and the benign hyperplasia can serve an additional criterion for
early diagnostics of pre-cancerous changes of the prostate gland.
Key words: prostate gland cancer, binign prostate hyperplasia, histohematogenous barrier
Back
Contents
Main
|
