DIFFERENTIATION OF THE COLON ENDOCRINE CELLS IN MUCOSAL EPITHELIUM OF HUMANS AND SOME
VERTEBRATE ANIMALS
S. V. Kostyukevitch
I. I. Mechnikov State Medical Academy, St. Petersburg, Russia;
e-mail: KSV@SK2945.spb.edu
By electron microscopy, the mucosal epithelium of a distal part of the intestine of humans and other vertebrates
(Rana temporaria, Lacerta vivipara, Columba livia, rabbit, rat, pig, cow) was examined. On the basis of the variety of cellular
structure and the level of specialization of the involved elements a common regularity of ways of differentiation of endocrine cells was
revealed. The updating of endocrine cells basically occurs as a result of differentiation of cambial cells through intermediate
pre-enteroendocrine forms. Reorganization of exoc-rine epithelial cells is accomplished through "mixed" exo-endocrine cells. At the
lower vertebrate animals the "mixed" cells are met much more frequently than in mammals, including man. In humans the greates
quantity of these cells is observed in the intra-uterine period of development and in cases of pathology. Ways of cytogenesis in endocrine
cells are differently manfested in the course of ontogenesis and under broken ability to live.
Key words: vertebrates, colon, epithelium, endocrine cells, differentiation
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