THE ROLE OF IRON-REGULATED GENES IN MICROBIAL PATHOGENESIS
D. P. Kozyrev, 1 N. A. Vassinova
Department of Biophysics, St. Petersburg State Polytechnical University, St. Petersburg, Russia;
1 e-mail: wikey@stu.neva.ru
An important component of nonspecific defence of human or animal organisms against microbial invasion is
attempt to withhold growth-essential iron from invading bacteria. To overcome the barrier bacterial iron uptake systems is derepressed
at low iron concentrations. In many pathogenic and nonpathogenic bacteria the regulation of the corresponding genes depends on
the regulatory protein Fur. For cloning Fur-regulated loci, methods based on affinity of Fur to the corresponding promoter sites are used.
Key words: iron uptake, Fur represser, Fur-box, pathogenic bacteria
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