THE BEHAVIOR OF NUCLEI AND NUCLEOLAR ORGANIZING REGIONS IN CHROMOSOMES OF LYMPHOCYTES
ON DIFFERENT STAGES OF PERIODIC DISEASE
E. M. Karalova, L. O. Abroyan, L. H. Hakopyan, K. G. Karagyozyan, Yu. A, Magakian
Institute of Molecular Biology, National Academy of Sciences of Armenia, Yerevan
By scanning cytomorphometry a cytological study was first performed on the behavior of nuclei and nucleolar
organizing regions (NOR) in chromosomes of peripheral blood lymphocytes of healthy men and of patients with periodic disease
(familial Mediterranean fever, FMF) on different stages of development, including its complication with amyloidosis. The volume and total
surface of nuclei, the sum total volume and sum total surlace of NOR, the mean number of NOR for one nucleus and distribution of nuclei
according to NOR number were measured. It is shown that the parameters of nuclei and NOR for patients with FMF on all stages clearly
and trustworthy differ from those for healthy men. They are sufficiently informative, can be successfully used in clinical practice and even
serve as an early diagnostic test for amyloidosis complication.
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