THE ROLE OF PHOSPHOINOSITIDE SIGNALING IN THE LOWER EUKARYOTES
I. V. Shemarova
The I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg;
e-mail: irina@lis.mail.icphb.ru
The recent achivements on phosphoinositide signaling in the unicellular eukaryotes have been reviewed.
Special attention is paid to mechanisms of phospholipase C (PLC) activation and its interaction with both cell surface receptors and
effector cytoplasm targets. We discuss the role of protein kinase C (PKC) in intracellular signaling, and the relationship between the
Pi-signal pathway key enzymes with protein kinases of cAMP-PKA and MAP-kinase pathways.
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